Oxbryta Lawsuits

Investigating Vaso-Occlusive Crisis Injuries Nationwide

Robert Peirce & Associates, P.C. is currently reviewing claims on behalf of individuals who took Oxbryta (voxelotor) and suffered serious complications, including vaso-occlusive crises, stroke, organ failure, or death.

Oxbryta was developed to treat complications of Sickle Cell Disease (SCD) by increasing hemoglobin levels and reducing red blood cell destruction. However, emerging reports and adverse event data suggest that this medication may be linked to life-threatening events, including vaso-occlusive episodes — the very complications it was designed to help prevent.

If you or someone you love experienced a serious medical crisis after taking Oxbryta, you may have a claim. Call (844) 383-0565 or contact us online for a FREE consultation.

Why Choose Robert Peirce & Associates, P.C.?

Robert Peirce & Associates, P.C. is a trusted civil trial firm with decades of experience handling complex product liability and defective drug cases. Our attorneys represent individuals and families harmed by dangerous pharmaceutical products — and we know how to hold manufacturers accountable.

Clients and referring counsel trust our team because:

• We’ve secured millions in verdicts and settlements in high-stakes injury claims.
• Our attorneys have decades of trial and negotiation experience.
• We provide individualized, strategic counsel from start to finish.
• We fight for real answers, real accountability, and real compensation.

If you’ve suffered complications after taking Oxbryta, we’re ready to help you explore your legal options and determine if you're eligible to pursue a claim.

Do I Have an Oxbryta Lawsuit?

You may have a viable Oxbryta lawsuit if:

• You or a loved one were prescribed Oxbryta (voxelotor) for Sickle Cell Disease; and
• After taking the medication, experienced one or more of the following serious complications:
  • Vaso-occlusive crisis (VOC)
  • Organ failure (e.g. kidney, liver, or multi-organ failure)
  • Stroke
  • Uncontrolled swelling, fever, or extreme pain
  • Death linked to a suspected VOC or organ shutdown

Oxbryta was marketed as a breakthrough therapy for Sickle Cell Disease, but for some patients, it may have triggered or worsened the complications it was intended to treat. Adverse outcomes linked to the drug have prompted increased scrutiny and legal review.

If your medical records show a connection between Oxbryta use and these life-threatening events, you may be entitled to pursue financial compensation through a defective drug claim.

What Is Oxbryta?

Oxbryta (voxelotor) is an oral prescription drug developed by Global Blood Therapeutics (acquired by Pfizer) and approved by the FDA in 2019. It is indicated for the treatment of Sickle Cell Disease (SCD) in patients aged 4 and older.

Oxbryta is designed to increase hemoglobin levels by inhibiting sickle hemoglobin polymerization — a central process in the pathophysiology of SCD. The goal is to reduce the frequency and severity of complications such as anemia and vaso-occlusive crises.

Despite its intended purpose, emerging data suggests that Oxbryta may not adequately prevent VOCs in all patients and, in some cases, may be associated with serious adverse effects.

Vaso-Occlusive Crisis and Other Complications

A vaso-occlusive crisis (VOC) is a painful and dangerous complication of Sickle Cell Disease in which sickled red blood cells block blood flow in small vessels. This can result in tissue damage, stroke, and organ failure.

Symptoms include:

• Severe pain, especially in the limbs, chest, or abdomen
• Fever and swelling
• Shortness of breath or chest pain
• Signs of kidney or liver distress
• Neurological changes indicating stroke

While Oxbryta was approved to reduce the risk of these complications, reports have surfaced of patients developing acute VOCs and organ-related injuries after starting the medication, raising concerns about whether the drug may, in some patients, contribute to or fail to prevent these events.

Allegations Against Oxbryta’s Manufacturer

Lawsuits involving Oxbryta allege that the drug’s manufacturer:

• Failed to adequately warn patients and physicians of the risks associated with the drug, particularly the potential for VOCs and organ damage
• Misrepresented the effectiveness of Oxbryta in preventing vaso-occlusive events
• Neglected post-market surveillance and failed to act on signals of harm from adverse event reports
• Released a drug that may be defectively designed or insufficiently tested for certain high-risk populations

These allegations may form the basis for product liability lawsuits brought by affected patients and their families.

Pfizer Recalls Oxbryta After Identifying Severe Risks

On September 25, 2024, Pfizer voluntarily withdrew Oxbryta (voxelotor) from the U.S. market, citing serious safety concerns uncovered during post-marketing clinical trials. The drug, originally granted accelerated FDA approval in 2019, was one of the few available oral treatments for patients with Sickle Cell Disease.

According to Pfizer, emerging data showed that the risks associated with Oxbryta outweighed its benefits for the approved patient population. The company stated:

“The overall benefit of Oxbryta no longer outweighs the risk in the approved sickle cell patient population.”

This full-market withdrawal followed growing reports of life-threatening complications, including vaso-occlusive crises, organ failure, and death. The recall has heightened scrutiny of how the drug was tested, marketed, and monitored, and is likely to play a significant role in supporting future claims by injured patients and their families.

If you or a loved one experienced severe medical complications after taking Oxbryta, this recall may strengthen your legal claim.

Compensation in Oxbryta Lawsuits

If you suffered serious injury or lost a loved one due to Oxbryta-related complications, you may be entitled to compensation for:

• Medical expenses related to hospitalization, surgery, or ongoing care
• Lost income or diminished earning capacity
• Pain and suffering, including chronic pain or disability
• Wrongful death damages for surviving family members
• Loss of quality of life or long-term care needs

Each case is unique. Compensation will depend on the nature and severity of your injuries and the strength of the medical evidence linking those injuries to Oxbryta use.

What Should I Do If I Think I Have a Case?

If you believe Oxbryta may have caused a serious medical event for you or a loved one, we encourage you to:

1. Secure your medical records, including your Oxbryta prescription history and any hospitalization or treatment following complications.
2. Document symptoms or diagnoses you experienced after taking the medication.
3. Contact a qualified attorney to evaluate whether you have a viable legal claim.

Our team at Robert Peirce & Associates, P.C. can help you determine eligibility, gather evidence, and file a claim — all at no upfront cost to you.

Frequently Asked Questions (FAQ)

How Do I Know If Oxbryta Caused My Injuries?

A review of your medical history, prescription records, and diagnostic testing can help establish whether Oxbryta may have played a role in your complications. Our attorneys work with medical experts to evaluate causation in these cases.

Is There an Ongoing Lawsuit Against Oxbryta?

As of now, lawsuits are being files against Pfizer and Global Blood Therapeutics, which initially developed the medication. We are actively investigating cases involving Oxbryta-related vaso-occlusive crises, organ failure, and death. Eligible claimants may be able to join future consolidated litigation or pursue individual claims.

How Long Do I Have to File a Lawsuit?

Each state has its own statute of limitations for defective drug claims — often between 1 to 3 years from the date of injury or discovery. If you're unsure of your timeline, we recommend contacting us immediately to preserve your rights.

How Much Does It Cost to Hire Your Firm?

We represent clients in defective drug cases on a contingency fee basis. That means there are no legal fees unless we win your case. Your consultation is free, confidential, and comes with no obligation.

Call for a FREE Consultation: (844) 383-0565

If you or someone you love experienced a vaso-occlusive crisis, organ failure, or stroke after taking Oxbryta, you may be entitled to financial compensation. These are serious, life-altering events — and they deserve serious legal attention.

Call (844) 383-0565 or contact us online for a free case evaluation. We’re here to help you understand your rights, weigh your options, and fight for the accountability and justice you deserve.